hrp0094p1-177 | Growth Hormone and IGFs B | ESPE2021

Immunogenicity of recombinant growth hormone and relationship its growth-promoting effect in the children with short stature

Karaoglan Murat , Isbilen Elif , Keskin Mehmet ,

Background/Aim: Although there are many well-known components that affect the growth response to recombinate growth hormone (rGH), its effect on total height gain is still not fully predictable. Current knowledge on the relationship between growth response to rGH and its immunogenicity is limited. The aim of the study was to reveal its relationship with the antibody formation against rGH and growth-promoting effect.Materials and Methods:...

hrp0094p2-269 | Growth hormone and IGFs | ESPE2021

Immunogenicity of recombinant growth hormone therapy in the children with short stature and consequences on growth-promoting effect

Karaoglan Murat , Isbilen Elif , Keskin Mehmet ,

Background/Aim: Although there are many well-known components that affect the growth response to recombinant growth hormone (rGH), its effect on total height gain is still not fully predictable. A limited number of studies have been reported revealing up-to-date data on the relationship between immunogenicity and growth-promoting effects of rGH. The study aimed to examine the antibody formation against rGH and its consequences on growth-promoting effect in chi...